Measuring T1ρ Changes Related to Acidosis and Alkalosis

Introduction While the brain maintains a constant pH level globally, local variations in pH may play a significant role in brain function. The ability to image pH dynamics could offer a novel, more direct approach to map brain function as well as detect disease and assess treatment response. In this study, we evaluated the utility of an MR imaging technique known as T1ρ, T1 relaxation in the rotating frame, to measures pH dynamics. The sensitivity of T1ρ to changes in pH was evaluated in both phantoms and an in vivo mouse model using a set of pharmacological challenges. Real-time fiber optic monitoring of pH was employed throughout the in vivo imaging experiment.